Prytkova, Iya and Brennand, Kristen J. (2017) Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells. Frontiers in Cellular Neuroscience, 11. ISSN 1662-5102
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Abstract
Excitatory dopaminergic neurons, inhibitory GABAergic neurons, microglia, and oligodendrocytes have all been implicated in schizophrenia (SZ) network pathology. Still, SZ has been a difficult disorder to study, not only because of the limitations of animal models in capturing the complexity of the human mind, but also because it is greatly polygenic, with high rates of variability across the population. The advent of patient-derived pluripotent stem cells and induced neural and glial cultures has brought hope for modeling the molecular dysfunction underlying SZ pathology in a patient-specific manner. Here I review the successes of the patient-specific induced cultures in generating different cell types for the study of SZ, with special emphasis on the utility of co-culture techniques, both two- and three-dimensional, for modeling network dysfunction in disease.
Item Type: | Article |
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Subjects: | Lib Research Guardians > Medical Science |
Depositing User: | Unnamed user with email support@lib.researchguardians.com |
Date Deposited: | 05 Jun 2023 06:09 |
Last Modified: | 20 Jan 2024 10:49 |
URI: | http://journal.edit4journal.com/id/eprint/1211 |