Cyto-Biological Activities of Lactaptin: An Insight into Designing of New Cancer Therapautics

Background and Objectives: Designing of effective anticancer-based peptides has been challenging these days probably due to the instability of the peptides in serum as well as low sensitivity and resistance of cancer cells to these peptides.

Methodology: published papers addressing anticancer activity of lactaptin has been reviewed extensively.

Results: Lactaptin, a peptide from proteolytic cleave of kappa casein human milk has been shown to play a number of roles including Program cell death, Genetic material fragmentation, suppression of metastasis, cytotoxicity to the cancer cells as well as caspases activation.

Conclusions: Lactaptin shows promising activity against cancer cells. Accordingly, enhancing lactaptin activity will greatly enhance its therapeutic efficacy and will provide insight into designing of new therapeutics.