Shi, Meng-meng and Shi, Chang-he and Xu, Yu-ming (2017) Rab GTPases: The Key Players in the Molecular Pathway of Parkinson’s Disease. Frontiers in Cellular Neuroscience, 11. ISSN 1662-5102
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Abstract
Parkinson’s disease (PD) is a progressive movement disorder with multiple non-motor symptoms. Although family genetic mutations only account for a small proportion of the cases, these mutations have provided several lines of evidence for the pathogenesis of PD, such as mitochondrial dysfunction, protein misfolding and aggregation, and the impaired autophagy-lysosome system. Recently, vesicle trafficking defect has emerged as a potential pathogenesis underlying this disease. Rab GTPases, serving as the core regulators of cellular membrane dynamics, may play an important role in the molecular pathway of PD through the complex interplay with numerous factors and PD-related genes. This might shed new light on the potential therapeutic strategies. In this review, we emphasize the important role of Rab GTPases in vesicle trafficking and summarize the interactions between Rab GTPases and different PD-related genes.
Item Type: | Article |
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Subjects: | Lib Research Guardians > Medical Science |
Depositing User: | Unnamed user with email support@lib.researchguardians.com |
Date Deposited: | 27 Jun 2023 07:02 |
Last Modified: | 28 Oct 2023 04:37 |
URI: | http://journal.edit4journal.com/id/eprint/1442 |