Liu, Hanxiao and Badawy, Mohamed and Sun, Shaoqin and Cruz, George and Ge, Shaoyu and Xiong, Qiaojie (2022) Microglial repopulation alleviates age-related decline of stable wakefulness in mice. Frontiers in Aging Neuroscience, 14. ISSN 1663-4365
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Abstract
Changes in wake/sleep architecture have been observed in both aged human and animal models, presumably due to various functional decay throughout the aging body particularly in the brain. Microglia have emerged as a modulator for wake/sleep architecture in the adult brain, and displayed distinct morphology and activity in the aging brain. However, the link between microglia and age-related wake/sleep changes remains elusive. In this study, we systematically examined the brain vigilance and microglia morphology in aging mice (3, 6, 12, and 18 months old), and determined how microglia affect the aging-related wake/sleep alterations in mice. We found that from young adult to aged mice there was a clear decline in stable wakefulness at nighttime, and a decrease of microglial processes length in various brain regions involved in wake/sleep regulation. The decreased stable wakefulness can be restored following the time course of microglia depletion and repopulation in the adult brain. Microglia repopulation in the aging brain restored age-related decline in stable wakefulness. Taken together, our findings suggest a link between aged microglia and deteriorated stable wakefulness in aged brains.
Item Type: | Article |
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Subjects: | Lib Research Guardians > Medical Science |
Depositing User: | Unnamed user with email support@lib.researchguardians.com |
Date Deposited: | 04 Oct 2023 05:31 |
Last Modified: | 04 Oct 2023 05:31 |
URI: | http://journal.edit4journal.com/id/eprint/1606 |