The Significance of Oral Fusobacterium nucleatum in Female Breast Cancer: A Brief Overview

This systematic review and meta-analysis implies a significant relationship between oral FN species and their role in female-specific BC pathogenesis, highlighting their bio- marker potentiality. The most common cancer in the world, breast cancer has an increasing incidence and is more likely to affect postpubertal females from all racial and ethnic backgrounds. Recent findings of oral Fusobacterium nucleatum species in cancerous human breast tissue have highlighted the importance of microbes in the pathogenesis of cancer. This systematic review was created in accordance with the preferred reporting system for systematic reviews and meta-analyses (PRISMA). AXIS tool analysis revealed 78.70% of articles with a positive correlation between oral Fusobacterium nucleatum and female-specific breast cancer. The risk of breast cancer development increased with significant levels of oral Fusobacterium nucleatum due to gingivitis/ periodontitis (relative risk = 1.78, 95% confidence interval = 1.63–1.91). Low-moderate statistical heterogeneity was found (I2 = 41.39%; P = 0.02), and the importance of periodontal status on breast cancer pathogenesis was determined (relative risk = 1.24, 95% confidence interval = 1.01–1.30). Oral Fusobacterium nucleatum species are a risk factor for breast cancer development, thus elevating their biomarker potentiality. Our findings increase understanding of the complexities of this relationship with regard to adult female populations and may be able to lower/prevent the risk of BC development globally, fundamentally altering the course of both medical and dental prognostics.