Abnormal Methylation Enzymes as the Most Critical Issue of Cancer

The objective of this study is to present convincing evidence to show that abnormal methylation enzymes (MEs) are the most critical issue of cancer, and to call for the acceptance of cell differentiation agent (CDA) formulations as the right medicines for cancer therapy. CDA formulations are the creation of the nature to function as allosteric regulators to keep abnormal MEs under control. Cancer is a disease caused by multiple factors. Toxic insults inducing cachexia symptoms to trigger a cascade of events resulting in the collapse of chemo-surveillance, which is an important allosteric mechanism to prevent the build up of cells with abnormal MEs; evolution of cancer stem cells (CSCs) from progenitor stem cells (PSCs) due to wound unhealing; and the activation of oncogenes and/or the inactivation of suppressor genes to play important roles to cause cancer. Among these multiple factors, abnormal MEs are the most critical issue of cancer. MEs play an important role on the regulation of cell replication and differentiation. This biological role is so important, so that MEs are subject to double allosteric regulations, one at the individual enzyme level and another at the enzyme complex level. When MEs become abnormal, cells are locked in perpetual state of proliferation which is the most outstanding feature of cancer. The solution of perpetual proliferation of cancer cells (CCs) is a very important issue of cancer. Killing of replicating cells and induction of terminal differentiation of replicating cells are two options to stop perpetual proliferations. The strategy based on killing of replicating cells displays the features as anti-wound healing and contra-indication of cancer therapy, whereas the strategy based on the induction of terminal differentiation displays the features as pro-wound healing and the right indication of cancer therapy. Evidently, the pro-wound healing strategy is the right approach of cancer therapy. A right approach is a golden rule to dictate the success to solve difficult challenges. Destabilization of abnormal MEs is the critical mechanism to achieve terminal differentiation of cells with abnormal MEs. Since abnormal MEs are most critical issue of cancer, the solution of cancer is best achieved by CDA formulations, the creation of the nature on allosteric regulation to take care of the issue of abnormal MEs.