Study on Diabetes Complications: A New Perspective on the Mechanism of Their Development

Diabetes complications involve organs with microcirculation (brain, eye, heart, kidney, skin) where glucose-fuelled energy production in the body takes place. The energy production in the cells in the microcirculation is sensitive to changes in quantity and quality of the equilibrated blood. The reaction of the body to these changes is responsible for the development of diabetes complications. Many of the pathogenic pathways known to mediate diabetic complications are associated with the accumulation of advanced glycation end products and/or activation of their downstream signalling pathways.

Long-term chronic diabetes complications occur when the volume of equilibrated blood is reduced as a result of vasoconstriction in the microcirculation. The corrective measures taken to optimize energy production result in organ damage and dysfunction – diabetes complication. These complications affect patients of both diabetes insipidus and diabetes mellitus.

“Hypo” and “Hyper” are complications exclusive to diabetes mellitus patients. They are the body’s response to attempt to alter the quality of the equilibrated blood in the microcirculation.

Insulin deficiency destroys the glucose/glycogen equilibrium that keeps blood plasma glucose concentration constant. This results in wild swings from the equilibrium blood glucose concentration. “Hypo” results from low glucose concentration, and “hyper” from high concentration.

With the aid of the new polyuria paradigm it has been possible to show that diabetes complications result from the body resisting interference in the glucose-fuelled energy production process in organs with microcirculation.